Article
Protease-activated receptor-1 contributes to cardiac remodeling and hypertrophy.
Circulation - 13 Nov 2007
Pawlinski Rafal, Tencati Michael, Hampton Craig R, Shishido Tetsuro, Bullard Tara A, Casey Liam M, Andrade-Gordon Patricia, Kotzsch Matthias, Spring Denise, Luther Thomas, Abe Jun-ichi, Pohlman Timothy H, Verrier Edward D, Blaxall Burns C, Mackman Nigel
Abstract excerpt
BACKGROUND: Protease-activated receptor-1 (PAR-1) is the high-affinity receptor for the coagulation protease thrombin. It is expressed by a variety of cell types in the heart, including cardiomyocytes and cardiac fibroblasts. We have shown that tissue factor (TF) and thrombin contribute to infarct size after cardiac ischemia-reperfusion (I/R) injury. Moreover, in vitro studies have shown that PAR-1 signaling...
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