Impact of myocardial infarct proteins and oscillating pressure on the differentiation of mesenchymal stem cells: effect of acute myocardial infarction on stem cell differentiation.

doi:10.1634/stemcells.2007-0708

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Impact of myocardial infarct proteins and oscillating pressure on the differentiation of mesenchymal stem cells: effect of acute myocardial infarction on stem cell differentiation.

Stem cells (Dayton, Ohio) - 1 Jul 2008

Chang Sung-A, Lee Eun Ju, Kang Hyun-Jae, Zhang Shu-Ying, Kim Ji-Hyun, Li Lian, Youn Seock-Won, Lee Choon-Soo, Kim Keum-Hyun, Won Joo-Yun, Sohn Jong-Woo, Park Kyung-Woo, Cho Hyun-Jai, Yang Sung-Eun, Oh Won Il, Yang Yoon Sun, Ho Won-Kyung, Park Young-Bae, Kim Hyo-Soo

Abstract excerpt

Stem cell transplantation in acute myocardial infarction (AMI) has emerged as a promising therapeutic option. We evaluated the impact of AMI on mesenchymal stem cell (MSC) differentiation into cardiomyocyte lineage. Cord blood-derived human MSCs were exposed to in vitro conditions simulating in vivo environments of the beating heart with acute ischemia, as follows: (a) myocardial proteins or serum obtained from...

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PMID: 18403756
DOI: 10.1634/stemcells.2007-0708

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