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Article

The Accelerated Evolution of Lagging Strand Genes Is Independent of Sequence Context.

Genome biology and evolution - 1 Dec 2016

Merrikh Christopher N, Weiss Eli, Merrikh Houra

Abstract excerpt

We previously discovered that lagging strand genes evolve faster in Bacillus subtilis (and potentially other bacteria). Lagging strand genes are transcribed in the head-on orientation with respect to DNA replication, leading to collisions between the two machineries that stall replication and can destabilize genomes. Our previous work indicated that the increased mutagenesis of head-on genes depends on...

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PMID: 28039230
DOI: 10.1093/gbe/evw274
PMCID: PMC5585990

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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