GC skew in protein-coding genes between the leading and lagging strands in bacterial genomes: new substitution models incorporating strand bias.

Abstract excerpt

The DNA strands in most prokaryotic genomes experience strand-biased spontaneous mutation, especially C-->T mutations produced by deamination that occur preferentially in the leading strand. This has often been invoked to account for the asymmetry in nucleotide composition, typically measured by GC skew, between the leading and the lagging strand. Casting such strand asymmetry in the framework of a nucleotide...

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