Article
Why are genes encoded on the lagging strand of the bacterial genome?
Genome biology and evolution - 1 Jan 2013
Chen Xiaoshu, Zhang Jianzhi
Abstract excerpt
Genomic DNA is used as the template for both replication and transcription, whose machineries may collide and result in mutagenesis, among other damages. Because head-on collisions are more deleterious than codirectional collisions, genes should be preferentially encoded on the leading strand to avoid head-on collisions, as is observed in most bacterial genomes examined. However, why are there still lagging...
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