Article
Co-orientation of replication and transcription preserves genome integrity.
PLoS genetics - 15 Jan 2010
Srivatsan Anjana, Tehranchi Ashley, MacAlpine David M, Wang Jue D
Abstract excerpt
In many bacteria, there is a genome-wide bias towards co-orientation of replication and transcription, with essential and/or highly-expressed genes further enriched co-directionally. We previously found that reversing this bias in the bacterium Bacillus subtilis slows replication elongation, and we proposed that this effect contributes to the evolutionary pressure selecting the transcription-replication...
Topics
- Bacillus subtilis
- DNA Replication
- Genome, Bacterial
- Mutation
- Transcription, Genetic