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Article

Therapeutic potential of the metabolic modulator phenformin in targeting the stem cell compartment in melanoma.

Oncotarget - 24 Jan 2017

Petrachi Tiziana, Romagnani Alessandra, Albini Adriana, Longo Caterina, Argenziano Giuseppe, Grisendi Giulia, Dominici Massimo, Ciarrocchi Alessia, Dallaglio Katiuscia

Abstract excerpt

Melanoma is the most dangerous and treatment-resistant skin cancer. Tumor resistance and recurrence are due to the persistence in the patient of aggressive cells with stem cell features, the cancer stem cells (CSC). Recent evidences have shown that CSC display a distinct metabolic profile as compared to tumor bulk population: a promising anti-tumor strategy is therefore to target specific metabolic pathways...

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Identifiers

PMID: 28036292
DOI: 10.18632/oncotarget.14321
PMCID: PMC5351679

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MITF
SOX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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