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ALDH1A Isozymes are Markers of Human Melanoma Stem Cells and Potential Therapeutic Targets

7 Aug 2012

Abstract excerpt

Although the concept of cancer stem cells (CSCs) is well-accepted for many tumors, the existence of such cells in human melanoma has been the subject of debate. In this study, we demonstrate the existence of human melanoma cells that fulfill the criteria for CSCs (self-renewal and differentiation) by serially xenotransplanting cells into nonobese diabetic/severe combined immunodeficiency (NOD/SCID) mice. These...

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PMID: 22887839
DOI: 10.1002/stem.1193

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