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Article

Sphere formation and self-renewal capacity of melanoma cells is affected by the microenvironment.

Melanoma research - 1 Jun 2012

Sztiller-Sikorska Malgorzata, Koprowska Kamila, Jakubowska Justyna, Zalesna Izabela, Stasiak Marta, Duechler Markus, Czyz Malgorzata Ewa

Abstract excerpt

Melanomas contain subsets of cancer stem-like cells with tumor-initiating capacity. The frequency of these cells in the tumor is still a topic of debate. We investigated the phenotypic plasticity of cancer cells grown as melanospheres to elucidate the influence of the microenvironment on some features of melanoma stem-like cells. Cells from surgical specimens of nodular melanoma were grown as...

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Source

Identifiers

PMID: 22495670
DOI: 10.1097/CMR.0b013e3283531317

Genes

ABCB5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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