Article
ΔNp73 overexpression promotes resistance to apoptosis but does not cooperate with PML/RARA in the induction of an APL-leukemic phenotype.
Oncotarget - 31 Jan 2017
Lucena-Araujo Antonio R, Coelho-Silva Juan L, Pereira-Martins Diego A, Thomé Carolina, Scheucher Priscila S, Lange Ana P, Paiva Helder H, Hemmelgarn Benjamin T, Morais-Sobral Mariana C, Azevedo Elisa A, Franca-Neto Pedro L, Franca Rafael F, Silva Cleide L, Krause Alexandre, Rego Eduardo M
Abstract excerpt
Here, we evaluated whether the overexpression of transcriptionally inactive ΔNp73 cooperates with PML/RARA fusion protein in the induction of an APL-leukemic phenotype, as well as its role in vitro in proliferation, myeloid differentiation, and drug-induced apoptosis. Using lentiviral gene transfer, we showed in vitro that ΔNp73 overexpression resulted in increased proliferation in murine bone marrow (BM) cells...
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