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Article

A naturally occurring p73 mutation in a p73-p53 double-mutant lung cancer cell line encodes p73 alpha protein with a dominant-negative function.

Cancer science - 1 Aug 2003

Huqun, Endo Yoshiyuki, Xin Hong, Takahashi Mitsu, Nukiwa Toshihiro, Hagiwara Koichi

Abstract excerpt

p73, a close homolog of p53 tumor suppressor, induces growth arrest and apoptosis. However, its role in cancers is controversial because of the rarity of p73 mutations, lack of tumors in p73-knockout mice, and the presence of multiple isotypes, among which Delta N isotypes inhibit the function of...

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Source

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Identifiers

PMID: 12901798
DOI: 10.1111/j.1349-7006.2003.tb01508.x
PMCID: PMC11160092

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12901798-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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