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Article

A splicing variant of the RON transcript induces constitutive tyrosine kinase activity and an invasive phenotype.

Molecular and cellular biology - 1 Oct 1996

Collesi C, Santoro M M, Gaudino G, Comoglio P M

Abstract excerpt

The Ron tyrosine kinase receptor shares with the members of its subfamily (Met and Sea) a unique functional feature: the control of cell dissociation, motility, and invasion of extracellular matrices (scattering). The mature Ron protein is a heterodimer of disulfide-linked alpha and beta chains,...

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Identifiers

PMID: 8816464
DOI: 10.1128/MCB.16.10.5518
PMCID: PMC231551

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-8816464-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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A splicing variant of the RON transcript induces constitutive tyrosine kinase activity and an invasive phenotype.PMID 8816464Read ↗

A novel variant of the RON receptor tyrosine kinase derived from colorectal carcinoma cells which lacks tyrosine phosphorylation but induces cell migration.Semantic proximity Read ↗

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Oncogenesis of RON receptor tyrosine kinase: a molecular target for malignant epithelial cancers.Semantic proximity Read ↗

Alterations in a defined extracellular region of the RON receptor tyrosine kinase promote RON-mediated motile and invasive phenotypes in epithelial cells.Semantic proximity Read ↗

Constitutive Activation of the RON Gene Promotes Invasive Growth but Not TransformationSemantic proximity Read ↗

Altered expression of the RON receptor tyrosine kinase in primary human colorectal adenocarcinomas: generation of different splicing RON variants and their oncogenic potential.Semantic proximity Read ↗

An Introduction and Overview of RON Receptor Tyrosine Kinase SignalingSemantic proximity Read ↗

Integrative genomic analyses of recepteur d'origine nantais and its prognostic value in cancer.Semantic proximity Read ↗

A novel protein isoform of the RON tyrosine kinase receptor transforms human pancreatic duct epithelial cellsSemantic proximity Read ↗

Significance of the entire C-terminus in biological activities mediated by the RON receptor tyrosine kinase and its oncogenic variant RON160.Semantic proximity Read ↗

Pathogenesis of RON receptor tyrosine kinase in cancer cells: activation mechanism, functional crosstalk, and signaling addictionSemantic proximity Read ↗

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