BAP1 Is Altered by Copy Number Loss, Mutation, and/or Loss of Protein Expression in More Than 70% of Malignant Peritoneal Mesotheliomas.

doi:10.1016/j.jtho.2016.12.019

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Article

BAP1 Is Altered by Copy Number Loss, Mutation, and/or Loss of Protein Expression in More Than 70% of Malignant Peritoneal Mesotheliomas.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Apr 2017

Leblay Noémie, Leprêtre Frédéric, Le Stang Nolwenn, Gautier-Stein Amandine, Villeneuve Laurent, Isaac Sylvie, Maillet Denis, Galateau-Sallé Françoise, Villenet Céline, Sebda Shéhérazade, Goracci Alexandra, Byrnes Graham, McKay James D, Figeac Martin, Glehen Olivier, Gilly François-Noël, Foll Matthieu, Fernandez-Cuesta Lynnette, Brevet Marie

Abstract excerpt

INTRODUCTION: Malignant mesothelioma is a deadly disease that is strongly associated with asbestos exposure. Peritoneal mesotheliomas account for 10% of all the cases. BRCA1 associated protein 1 (BAP1) is a deubiquitinating hydrolase that plays a key role in various cellular processes. Germline and somatic inactivation of BRCA1 associated protein 1 gene (BAP1) is frequent in pleural mesothelioma; however, little...

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Identifiers

PMID: 28034829
DOI: 10.1016/j.jtho.2016.12.019

Genes

BAP1
BRCA1

Provenance

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