Article
High Incidence of Somatic BAP1 alterations in sporadic malignant mesothelioma.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Apr 2015
Nasu Masaki, Emi Mitsuru, Pastorino Sandra, Tanji Mika, Powers Amy, Luk Hugh, Baumann Francine, Zhang Yu-An, Gazdar Adi, Kanodia Shreya, Tiirikainen Maarit, Flores Erin, Gaudino Giovanni, Becich Michael J, Pass Harvey I, Yang Haining, Carbone Michele
Abstract excerpt
BACKGROUND: Breast cancer 1-associated protein 1 (BAP1) is a nuclear deubiquitinase that regulates gene expression, transcription, DNA repair, and more. Several findings underscore the apparent driver role of BAP1 in malignant mesothelioma (MM). However, the reported frequency of somatic BAP1 mutations in MM varies considerably, a discrepancy that appeared related to either methodological or ethnical differences...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.