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Article

Complex ciprofloxacin resistome revealed by screening a Pseudomonas aeruginosa mutant library for altered susceptibility.

Antimicrobial agents and chemotherapy - 1 Dec 2008

Breidenstein Elena B M, Khaira Bhavjinder K, Wiegand Irith, Overhage Joerg, Hancock Robert E W

Abstract excerpt

Pseudomonas aeruginosa offers substantial therapeutic challenges due to its high intrinsic resistance to many antibiotics and its propensity to develop mutational and/or adaptive resistance. The PA14 comprehensive mutant library was screened for mutants exhibiting either two- to eightfold increased susceptibilities (revealing genes involved in intrinsic resistance) or decreased susceptibilities (mutational...

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Identifiers

PMID: 18824609
DOI: 10.1128/AAC.00222-08
PMCID: PMC2592849

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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