Article
Ciprofloxacin binding to GyrA causes global changes in the proteome of Pseudomonas aeruginosa.
FEMS microbiology letters - 1 Jul 2018
Jedrey Hannah, Lilley Kathryn S, Welch Martin
Abstract excerpt
Ciprofloxacin is one of the most widely-used antibiotics, and has proven especially effective at controlling infections associated with the opportunistic human pathogen, Pseudomonas aeruginosa. In this work, we show that sub-inhibitory concentrations of ciprofloxacin induce discrete changes in the intracellular proteome. Central metabolism and cell envelope-associated functions are particularly affected. In spite...
Topics
- Anti-Bacterial Agents
- Bacterial Proteins
- Ciprofloxacin
- DNA Gyrase
- Microbial Sensitivity Tests
- Mutation
- Proteome
- Pseudomonas aeruginosa