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Article

Upregulation of AcrEF in Quinolone Resistance Development in Escherichia coli When AcrAB-TolC Function Is Impaired.

Microbial drug resistance (Larchmont, N.Y.) - 1 Jan 2000

Zhang Chuan-Zhen, Chang Man-Xia, Yang Lei, Liu Yan-Yan, Chen Pin-Xian, Jiang Hong-Xia

Abstract excerpt

We studied mechanisms of drug resistance development in Escherichia coli strains lacking efflux pump components. E. coli K12 deletion mutants were subjected to increasing concentrations of ciprofloxacin (CIP) to determine the frequency of target gene mutations. We generated a series of mutants that were selected based on their minimum inhibitory concentrations (MICs) to CIP, as well as their corresponding point...

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PMID: 28520511
DOI: 10.1089/mdr.2016.0207

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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