Article
Anaplastic lymphoma kinase L1198F and G1201E mutations identified in anaplastic thyroid cancer patients are not ligand-independent.
Oncotarget - 14 Feb 2017
Guan Jikui, Wolfstetter Georg, Siaw Joachim, Chand Damini, Hugosson Fredrik, Palmer Ruth H, Hallberg Bengt
Abstract excerpt
Activating mutations in full length anaplastic lymphoma kinase (ALK) have been reported in neuroblastoma and in anaplastic thyroid cancer. ALK-L1198F and ALK-G1201E mutations were originally identified in anaplastic thyroid cancer (ATC) and characterized as constitutively activating mutations. In this study, we employed in vitro cell culture assays together with biochemical and in vivo Drosophila analyses to...
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