Association of granulomatosis with polyangiitis (Wegener's) with HLA-DPB1*04 and SEMA6A gene variants: evidence from genome-wide analysis.

doi:10.1002/art.38036

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Association of granulomatosis with polyangiitis (Wegener's) with HLA-DPB1*04 and SEMA6A gene variants: evidence from genome-wide analysis.

Arthritis and rheumatism - 1 Sept 2013

Xie Gang, Roshandel Delnaz, Sherva Richard, Monach Paul A, Lu Emily Yue, Kung Tabitha, Carrington Keisha, Zhang Steven S, Pulit Sara L, Ripke Stephan, Carette Simon, Dellaripa Paul F, Edberg Jeffrey C, Hoffman Gary S, Khalidi Nader, Langford Carol A, Mahr Alfred D, St Clair E William, Seo Philip, Specks Ulrich, Spiera Robert F, Stone John H, Ytterberg Steven R, Raychaudhuri Soumya, de Bakker Paul I W, Farrer Lindsay A, Amos Christopher I, Merkel Peter A, Siminovitch Katherine A

Abstract excerpt

OBJECTIVE: To identify genetic determinants of granulomatosis with polyangiitis (Wegener's) (GPA). METHODS: We carried out a genome-wide association study (GWAS) of 492 GPA cases and 1,506 healthy controls (white subjects of European descent), followed by replication analysis of the most strongly associated signals in an independent cohort of 528 GPA cases and 1,228 controls. RESULTS: Genome-wide significant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Frequency

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Association Studies

Share to Genome-Wide Association Study

Share to Granulomatosis with Polyangiitis

Share to Haplotypes

Share to HLA-DP beta-Chains

Share to Major Histocompatibility Complex

Share to Semaphorins

Source

Open in PubMed Open full text

Identifiers

PMID: 23740775
DOI: 10.1002/art.38036
PMCID: PMC4471994

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of granulomatosis with polyangiitis (Wegener's) with HLA-DPB1*04 and SEMA6A gene variants: evidence from genome-wide analysis.PMID 23740775Read ↗

Identification of Functional and Expression Polymorphisms Associated With Risk for Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis.Semantic proximity Read ↗

HLA sequencing identifies novel associations and suggests clinical relevance of DPB1*04:01 in ANCA-associated Granulomatosis with polyangiitis.Semantic proximity Read ↗

Meta-analysis of genetic polymorphisms in granulomatosis with polyangiitis (Wegener's) reveals shared susceptibility loci with rheumatoid arthritis.Semantic proximity Read ↗

Genetics of ANCA-associated vasculitides: HLA and beyond.Semantic proximity Read ↗

The Wegener's granulomatosis quantitative trait locus on chromosome 6p21.3 as characterised by tagSNP genotyping.Semantic proximity Read ↗

Familial granulomatosis with polyangiitis: three cases of this rare disorder in one Indoasian family carrying an identical HLA DPB1 allele.Semantic proximity Read ↗

Meta-analysis confirmed genetic susceptibility conferred by multiple risk variants from CTLA4 and SERPINA1 in granulomatosis with polyangiitis.Semantic proximity Read ↗

HLA-DPB1 variant rs3117242 is associated with anti-neutrophil cytoplasmic antibody-associated vasculitides in a Han Chinese population.Semantic proximity Read ↗

Genetics and pathophysiology of granulomatosis with polyangiitis (GPA) and its main autoantigen proteinase 3.Semantic proximity Read ↗

[Genetic risk factors for vasculitis].Semantic proximity Read ↗

Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Update: Genetic Pathogenesis.Semantic proximity Read ↗

Genetic associations of eosinophilic granulomatosis with polyangiitis in the Japanese population: Exploring similarities and differences with European populationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.