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Article

The Effects of Anti-CD3/CD28 Coated Beads and IL-2 on Expanded T Cell for Immunotherapy.

Advances in clinical and experimental medicine : official organ Wroclaw Medical University - 1 Jan 2000

Martkamchan Sirimarn, Onlamoon Nattawat, Wang Siyu, Pattanapanyasat Kovit, Ammaranond Palanee

Abstract excerpt

BACKGROUND: The activation of peripheral blood mononucleated cells (PBMCs) with anti-CD3/CD28-coated magnetic beads promotes intrinsic resistance to HIV as well as cell expansion. OBJECTIVES: The aim of this study was to define an optimal cell isolation protocol for the expansion of PBMCs using anti-CD3/CD28-coated bead stimulation, with the ultimate goal of using these cells for adoptive therapy. MATERIAL AND...

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PMID: 28028943
DOI: 10.17219/acem/35771

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