Article
The effect of artificial antigen-presenting cells with preclustered anti-CD28/-CD3/-LFA-1 monoclonal antibodies on the induction of ex vivo expansion of functional human antitumor T cells.
Haematologica - 1 Oct 2008
Zappasodi Roberta, Di Nicola Massimo, Carlo-Stella Carmelo, Mortarini Roberta, Molla Alessandra, Vegetti Claudia, Albani Salvatore, Anichini Andrea, Gianni Alessandro M
Abstract excerpt
BACKGROUND: Adoptive cell therapy with ex vivo expanded autologous antitumor cytotoxic T lymphocytes represents an important therapeutic option as an anticancer strategy. In order to identify a reliable method for producing adequate amounts of functional antitumor cytotoxic T lymphocytes with a potentially long in vivo lifespan, we tested the T-cell expansion efficiency of a new artificial antigen-presenting...
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