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Article

Analysis to Estimate Genetic Variations in the Idarubicin-Resistant Derivative MOLT-3

22 Dec 2016

Abstract excerpt

Gene alterations are a well-established mechanism leading to drug resistance in acute leukemia cells. A full understanding of the mechanisms of drug resistance in these cells will facilitate more effective chemotherapy. In this study, we investigated the mechanism(s) of drug resistance in the human acute leukemia cell line MOLT-3 and its idarubicin-resistant derivative MOLT-3/IDR through complete mitochondrial...

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PMID: 28025493
DOI: 10.3390/ijms18010012

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