Article
MM-TRAG (MGC4175), a novel intracellular mitochondrial protein, is associated with the taxol- and doxorubicin-resistant phenotype in human cancer cell lines.
Gene - 29 Sept 2004
Duan Zhenfeng, Brakora Katherine A, Seiden Michael V
Abstract excerpt
In the search for novel genes involved in the taxol resistance phenotype, prior studies of gene expression in taxol-resistant cell lines and their paired drug-sensitive parental lines using high-density Affymetrix microarrays identified MGC4175 as an overexpressed transcript. In this report, we characterize MGC4175 and demonstrate that seven of eight taxol- and doxorubicin-resistant cell lines overexpressed...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.