Article
Prognostic implications and molecular associations of NADH dehydrogenase subunit 4 (ND4) mutations in acute myeloid leukemia.
Leukemia - 1 Feb 2012
Damm F, Bunke T, Thol F, Markus B, Wagner K, Göhring G, Schlegelberger B, Heil G, Reuter C W M, Püllmann K, Schlenk R F, Döhner K, Heuser M, Krauter J, Döhner H, Ganser A, Morgan M A
Abstract excerpt
To study the prevalence and prognostic importance of mutations in NADH dehydrogenase subunit 4 (ND4), a mitochondrial encoded transmembrane component of the electron transport chain respiratory Complex I, 452 AML patients were examined for ND4 mutations by direct sequencing. The prognostic impact of ND4 mutations was evaluated in the context of other clinical prognostic markers and genetic risk factors. In all,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.