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Article

Analysis of single nucleotide polymorphism C3435T of the multidrug resistance gene MDR1 in acute lymphoblastic leukemia.

International journal of oncology - 1 Aug 2003

Efferth Thomas, Sauerbrey Axel, Steinbach Daniel, Gebhart Erich, Drexler Hans-Günther, Miyachi Hayato, Chitambar Christopher R, Becker Cord-Michael, Zintl Felix, Humeny Andreas

Abstract excerpt

Multidrug resistance is an important mechanism responsible for refractoriness of leukemia and worse outcome of patients. Overexpression of the multidrug resistance gene, MDR1, is of prognostic relevance in acute myeloid leukemia, while its role in acute lymphoblastic leukemia (ALL) is still under debate. Single nucleotide polymorphisms (SNP) have been detected in the MDR1 gene. The C3435T polymorphism in this...

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PMID: 12851703

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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