Article
Lack of Ubiquitin Specific Protease 8 (USP8) Mutations in Canine Corticotroph Pituitary Adenomas.
PloS one - 1 Jan 2016
Sbiera Silviu, Tryfonidou Marianna A, Weigand Isabel, Grinwis Guy C M, Broeckx Bart, Herterich Sabine, Allolio Bruno, Deutschbein Timo, Fassnacht Martin, Meij Björn P
Abstract excerpt
PURPOSE: Cushing's disease (CD), also known as pituitary-dependent hyperadrenocorticism, is caused by adrenocorticotropic hormone (ACTH)-secreting pituitary tumours. Affected humans and dogs have similar clinical manifestations, however, the incidence of the canine disease is thousand-fold higher. This makes the dog an obvious model for studying the pathogenesis of pituitary-dependent hyperadrenocorticism....
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