Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Angiotensin II increases glomerular permeability by β-arrestin mediated nephrin endocytosis.

Scientific reports - 22 Dec 2016

Königshausen Eva, Zierhut Ulf M, Ruetze Martin, Potthoff Sebastian A, Stegbauer Johannes, Woznowski Magdalena, Quack Ivo, Rump Lars C, Sellin Lorenz

Abstract excerpt

Glomerular permeability and subsequent albuminuria are early clinical markers for glomerular injury in hypertensive nephropathy. Albuminuria predicts mortality and cardiovascular morbidity. AT1 receptor blockers protect from albuminuria, cardiovascular morbidity and mortality. A blood pressure independent, molecular mechanism for angiotensin II (Ang II) dependent albuminuria has long been postulated. Albuminuria...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Albuminuria
Share to Angiotensin II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to beta-Arrestins

Share to Biotinylation

Share to Kidney Glomerulus

Share to Permeability

Share to Podocytes

Share to Type C Phospholipases

Source

Open in PubMed Open full text

Identifiers

PMID: 28004760
DOI: 10.1038/srep39513
PMCID: PMC5177899

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Angiotensin II increases glomerular permeability by β-arrestin mediated nephrin endocytosis.PMID 28004760Read ↗

Nephrin Signaling in the Podocyte: An Updated View of Signal Regulation at the Slit Diaphragm and BeyondSemantic proximity Read ↗

An update: the role of Nephrin inside and outside the kidneySemantic proximity Read ↗

ORAI channels are critical for receptor-mediated endocytosis of albumin.Semantic proximity Read ↗

CIN85 Deficiency Prevents Nephrin Endocytosis and Proteinuria in Diabetes.Semantic proximity Read ↗

Nephrin – a unique structural and signaling protein of the kidney filterSemantic proximity Read ↗

Nephrin Localizes at the Podocyte Filtration Slit Area and Is Characteristically Spliced in the Human KidneySemantic proximity Read ↗

Revisiting nephrin signaling and its specialized effects on the uniquely adaptable podocyteSemantic proximity Read ↗

Podocyte endocytosis in the regulation of the glomerular filtration barrierSemantic proximity Read ↗

The Importance of Podocyte Adhesion for a Healthy GlomerulusSemantic proximity Read ↗

Nephrin Signaling Results in Integrin β1 ActivationSemantic proximity Read ↗

Phosphorylation of nephrin triggers its internalization by raft-mediated endocytosis.Semantic proximity Read ↗

Autoantibodies against nephrin elucidate a novel autoimmune phenomenon in proteinuric kidney diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.