Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phosphorylation of nephrin triggers its internalization by raft-mediated endocytosis.

Journal of the American Society of Nephrology : JASN - 1 Dec 2009

Qin Xiao-Song, Tsukaguchi Hiroyasu, Shono Akemi, Yamamoto Akitsugu, Kurihara Hidetake, Doi Toshio

Abstract excerpt

Proper localization of nephrin determines integrity of the glomerular slit diaphragm. Slit diaphragm proteins assemble into functional signaling complexes on a raft-based platform, but how the trafficking of these proteins coordinates with their signaling function is unknown. Here, we demonstrate that a raft-mediated endocytic (RME) pathway internalizes nephrin. Nephrin internalization was slower with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endocytosis
Share to Endosomes
Share to In Vitro Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kidney Glomerulus

Share to L Cells

Share to Membrane Microdomains

Share to Microscopy, Immunoelectron

Share to Rats, Sprague-Dawley

Source

Open in PubMed Open full text

Identifiers

PMID: 19850954
DOI: 10.1681/ASN.2009010011
PMCID: PMC2794235

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phosphorylation of nephrin triggers its internalization by raft-mediated endocytosis.PMID 19850954Read ↗

Nephrin Signaling in the Podocyte: An Updated View of Signal Regulation at the Slit Diaphragm and BeyondSemantic proximity Read ↗

Selective endocytosis controls slit diaphragm maintenance and dynamicsSemantic proximity Read ↗

The function of endocytosis in podocytesSemantic proximity Read ↗

Revisiting nephrin signaling and its specialized effects on the uniquely adaptable podocyteSemantic proximity Read ↗

Selective endocytosis controls slit diaphragm maintenance and dynamics in Drosophila nephrocytesSemantic proximity Read ↗

An update: the role of Nephrin inside and outside the kidneySemantic proximity Read ↗

Podocyte endocytosis in the regulation of the glomerular filtration barrierSemantic proximity Read ↗

A flexible, multilayered protein scaffold maintains the slit in between glomerular podocytesSemantic proximity Read ↗

Nephrin localizes to the slit pore of the glomerular epithelial cellSemantic proximity Read ↗

Slit diaphragm maintenance requires dynamic clathrin-mediated endocytosis facilitated by AP-2, Lap, Aux and Hsc70-4 in nephrocytesSemantic proximity Read ↗

Nephrin – a unique structural and signaling protein of the kidney filterSemantic proximity Read ↗

Using Drosophila Nephrocytes to Understand the Formation and Maintenance of the Podocyte Slit DiaphragmSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.