Article
Differential roles of fibrinogen and von Willebrand factor on clot formation and platelet adhesion in reconstituted and immune thrombocytopenia.
Anesthesia and analgesia - 1 May 2011
Misgav Mudi, Shenkman Boris, Budnik Ivan, Einav Yulia, Martinowitz Uri
Abstract excerpt
BACKGROUND: Bleeding tendencies in immune thrombocytopenia (ITP) do not always correlate with the number of platelets, suggesting platelet function variation. We used a model of normal whole blood thrombocytopenia to compare platelet function and other hemostatic variables with ITP patients. We further investigated the effect of in vitro spiking with von Willebrand factor (vWF) and fibrinogen on platelet function...
Topics
- Adult
- Aged
- Aged, 80 and over
- Female
- Fibrinogen
- Hemorrhage
- Hemostasis
- Humans
- Male
- Middle Aged
- Phenotype
- Platelet Adhesiveness
- Platelet Aggregation
- Platelet Count
- Purpura, Thrombocytopenic, Idiopathic
- Thrombelastography
- Thrombocytopenia
- Thrombosis