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Article

SF1 Phosphorylation Enhances Specific Binding to U2AF65 and Reduces Binding to 3'-Splice-Site RNA.

Biophysical journal - 20 Dec 2016

Chatrikhi Rakesh, Wang Wenhua, Gupta Ankit, Loerch Sarah, Maucuer Alexandre, Kielkopf Clara L

Abstract excerpt

Splicing factor 1 (SF1) recognizes 3' splice sites of the major class of introns as a ternary complex with U2AF65 and U2AF35 splicing factors. A conserved SPSP motif in a coiled-coil domain of SF1 is highly phosphorylated in proliferating human cells and is required for cell proliferation. The UHM kinase 1 (UHMK1), also called KIS, double-phosphorylates both serines of this SF1 motif. Here, we use isothermal...

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Identifiers

PMID: 28002734
DOI: 10.1016/j.bpj.2016.11.007
PMCID: PMC5192697

Genes

UHMK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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