Article
Correlation between angiotensin-converting-enzyme 2 gene polymorphisms and systemic sclerosis.
Clinical and experimental rheumatology - 1 Aug 2023
Miziołek Bartosz, Kruszniewska-Rajs Celina, Gola Joanna, Bultrowicz Monika, Miszczyk Justyna, Pieczyrak Robert, Frątczak Aleksandra, Polak Karina, Kucharz Eugeniusz J, Bergler-Czop Beata
Abstract excerpt
OBJECTIVES: Systemic sclerosis (SSc) is a disease with cardiovascular impairment and polymorphisms of the gene coding of angiotensin-converting-enzyme 2 (ACE2) may account for its development. Three single nucleotide polymorphisms of ACE2 (C>G rs879922, G>A rs2285666 and A>G rs1978124) were found to increase the risk for development of arterial hypertension (AH) and cardiovascular (CVS) diseases in different...
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