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Article

Association of metalloproteinase gene polymorphisms with systemic sclerosis in the European Caucasian population.

The Journal of rheumatology - 1 Mar 2010

Wipff Julien, Dieude Philippe, Avouac Jerome, Tiev Kiet, Hachulla Eric, Cracowski Jean-Luc, Diot Elizabeth, Sibilia Jean, Mouthon Luc, Meyer Olivier, Kahan Andre, Boileau Catherine, Allanore Yannick

Abstract excerpt

OBJECTIVE: Systemic sclerosis (SSc) is classified among the complex genetic disorders and is characterized by massive extracellular matrix deposits. These may be due to overactivation of transforming growth factor ss that may be in part a result of abnormal remodeling of extracellular matrix and...

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Source

Identifiers

PMID: 20110530
DOI: 10.3899/jrheum.090973

Genes

MMP14
MMP2
MMP9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20110530-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

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Association of metalloproteinase gene polymorphisms with systemic sclerosis in the European Caucasian population.PMID 20110530Read ↗

Matrix metalloproteinase gene polymorphisms and susceptibility to systemic sclerosis.Semantic proximity Read ↗

Association of a functional polymorphism in the matrix metalloproteinase-12 promoter region with systemic sclerosis in an Italian population.Semantic proximity Read ↗

Analysis of matrix metalloproteinase-9 gene polymorphism -1562 C/T in patients suffering from systemic sclerosis with and without ulcers.Semantic proximity Read ↗

Lack of association of a functionally relevant single nucleotide polymorphism of matrix metalloproteinase-1 promoter with systemic sclerosis (scleroderma).Semantic proximity Read ↗

The -2518A>G promoter polymorphism in the CCL2 gene is not associated with systemic sclerosis susceptibility or phenotype: results from a multicenter study of European Caucasian patients.Semantic proximity Read ↗

Angiotensin-converting enzyme gene does not contribute to genetic susceptibility to systemic sclerosis in European Caucasians.Semantic proximity Read ↗

Single-nucleotide polymorphisms in CCL2 gene are not associated with susceptibility to systemic sclerosis.Semantic proximity Read ↗

Lack of association between three vascular endothelial growth factor gene polymorphisms and systemic sclerosis: results from a multicenter EUSTAR study of European Caucasian patients.Semantic proximity Read ↗

Correlation between angiotensin-converting-enzyme 2 gene polymorphisms and systemic sclerosis.Semantic proximity Read ↗

Polymorphisms in COL15 gene are not associated with systemic sclerosis.Semantic proximity Read ↗

Matrix metalloproteinase 9 (MMP-9) gene polymorphism and MMP-9 plasma levels in primary Sjogren's syndrome.Semantic proximity Read ↗

IL13RA2 gene polymorphisms are associated with systemic sclerosis.Semantic proximity Read ↗

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