Article
Mice lacking WRB reveal differential biogenesis requirements of tail-anchored proteins in vivo.
Scientific reports - 21 Dec 2016
Rivera-Monroy Jhon, Musiol Lena, Unthan-Fechner Kirsten, Farkas Ákos, Clancy Anne, Coy-Vergara Javier, Weill Uri, Gockel Sarah, Lin Shuh-Yow, Corey David P, Kohl Tobias, Ströbel Philipp, Schuldiner Maya, Schwappach Blanche, Vilardi Fabio
Abstract excerpt
Tail-anchored (TA) proteins are post-translationally inserted into membranes. The TRC40 pathway targets TA proteins to the endoplasmic reticulum via a receptor comprised of WRB and CAML. TRC40 pathway clients have been identified using in vitro assays, however, the relevance of the TRC40 pathway in vivo remains unknown. We followed the fate of TA proteins in two tissue-specific WRB knockout mouse models and found...
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