Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression of the Z Variant of α1-Antitrypsin Suppresses Hepatic Cholesterol Biosynthesis in Transgenic Zebrafish

27 Jan 2023

Abstract excerpt

Individuals homozygous for the Pi*Z allele of SERPINA1 (ZAAT) are susceptible to lung disease due to insufficient α1-antitrypsin secretion into the circulation and may develop liver disease due to compromised protein folding that leads to inclusion body formation in the endoplasmic reticulum (ER) of hepatocytes. Transgenic zebrafish expressing human ZAAT show no signs of hepatic accumulation despite displaying...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Complement system in diseases
Share to Signaling Pathways in Disease
Share to Trypanosoma species research and implications

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36768797
DOI: 10.3390/ijms24032475

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 18 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of the Z Variant of α1-Antitrypsin Suppresses Hepatic Cholesterol Biosynthesis in Transgenic ZebrafishPMID 36768797Read ↗

Alpha-1-antitrypsin deficiency: diagnosis, pathophysiology, and management.Semantic proximity Read ↗

Liver organoids reproduce alpha-1 antitrypsin deficiency-related liver diseaseSemantic proximity Read ↗

Novel Transgenic Humanized Alpha-1 Antitrypsin Deficiency Mouse Model on Murine <i>SERPINA1</i> Null BackgroundSemantic proximity Read ↗

CHOP and c-JUN up-regulate the mutant Z α1-antitrypsin, exacerbating its aggregation and liver proteotoxicity.Semantic proximity Read ↗

[Alpha-1-antitrypsin deficiency].Semantic proximity Read ↗

Alpha-1 antitrypsin deficiency-associated liver disease: From understudied disorder to the poster child of genetic medicine.Semantic proximity Read ↗

The discovery of α1-antitrypsin and its role in health and disease.Semantic proximity Read ↗

A C. elegans model of human α1-antitrypsin deficiency links components of the RNAi pathway to misfolded protein turnover.Semantic proximity Read ↗

Amelioration of Alpha-1 Antitrypsin Deficiency Diseases with Genome Editing in Transgenic Mice.Semantic proximity Read ↗

Advances in alpha-1-antitrypsin deficiency liver disease.Semantic proximity Read ↗

Effect of Alpha-1 Antitrypsin Deficiency on Zinc Homeostasis Genes Regulation and Interaction with Endoplasmic Reticulum Stress Response Associated GenesSemantic proximity Read ↗

Mysteries of α1-antitrypsin deficiency: emerging therapeutic strategies for a challenging diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.