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Article

CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis.

The Journal of cell biology - 27 Mar 2006

Shim Jae-Hyuck, Xiao Changchun, Hayden Matthew S, Lee Ki-Young, Trombetta E Sergio, Pypaert Marc, Nara Atsuki, Yoshimori Tamotsu, Wilm Bettina, Erdjument-Bromage Hediye, Tempst Paul, Hogan Brigid L M, Mellman Ira, Ghosh Sankar

Abstract excerpt

Charged MVB protein 5 (CHMP5) is a coiled coil protein homologous to the yeast Vps60/Mos10 gene and other ESCRT-III complex members, although its precise function in either yeast or mammalian cells is unknown. We deleted the CHMP5 gene in mice, resulting in a phenotype of early embryonic lethality, reflecting defective late endosome function and dysregulation of signal transduction. Chmp5-/- cells exhibit...

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Identifiers

PMID: 16567502
DOI: 10.1083/jcb.200509041
PMCID: PMC2063762

Genes

CHMP5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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