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Article

Reduced synaptic vesicle protein degradation at lysosomes curbs TBC1D24/sky-induced neurodegeneration.

The Journal of cell biology - 24 Nov 2014

Fernandes Ana Clara, Uytterhoeven Valerie, Kuenen Sabine, Wang Yu-Chun, Slabbaert Jan R, Swerts Jef, Kasprowicz Jaroslaw, Aerts Stein, Verstreken Patrik

Abstract excerpt

Synaptic demise and accumulation of dysfunctional proteins are thought of as common features in neurodegeneration. However, the mechanisms by which synaptic proteins turn over remain elusive. In this paper, we study Drosophila melanogaster lacking active TBC1D24/Skywalker (Sky), a protein that in humans causes severe neurodegeneration, epilepsy, and DOOR (deafness, onychdystrophy, osteodystrophy, and mental...

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Identifiers

PMID: 25422373
DOI: 10.1083/jcb.201406026
PMCID: PMC4242831

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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