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Article

HYAL-2–WWOX–SMAD4 Signaling in Cell Death and Anticancer Response

5 Dec 2016

Abstract excerpt

Hyaluronidase HYAL-2 is a membrane-anchored protein and also localizes, in part, in the lysosome. Recent study from animal models revealed that both HYAL-1 and HYAL-2 are essential for the metabolism of hyaluronan (HA). Hyal-2 deficiency is associated with chronic thrombotic microangiopathy with hemolytic anemia in mice due to over accumulation of high molecular size HA. HYAL-2 is essential for platelet...

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PMID: 27999774
DOI: 10.3389/fcell.2016.00141

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