Article

The chromatin-remodeling enzyme Smarca5 regulates erythrocyte aggregation via Keap1-Nrf2 signaling

2021-09-09

Abstract excerpt

Although thrombosis has been extensively studied using various animal models, however, our understanding of the underlying mechanism remains elusive. Here, using zebrafish model, we demonstrated that smarca5 -deficient red blood cells (RBCs) formed blood clots in the caudal vein plexus that mimics venous thrombosis. We further used the anti-thrombosis drugs to treat smarca5 zko1049a embryos and found that a thr...

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Literature Corpus work: 7913e6f5-f79b-533d-ad3e-57147a61d5fb
DOI: 10.1101/2021.09.08.459391

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