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Article

Impact of AIP and inhibitory G protein alpha 2 proteins on clinical features of sporadic GH-secreting pituitary adenomas.

European journal of endocrinology - 1 Feb 2017

Ritvonen Elina, Pitkänen Esa, Karppinen Atte, Vehkavaara Satu, Demir Hande, Paetau Anders, Schalin-Jäntti Camilla, Karhu Auli

Abstract excerpt

INTRODUCTION: In sporadic acromegaly, downregulation of AIP protein of the adenomas associates with invasive tumor features and reduced responsiveness to somatostatin analogues. AIP is a regulator of Gai signaling, but it is not known how the biological function of the Gai pathway is controlled. AIM: To study GNAS and AIP mutation status, AIP and Gai-2 protein expressions, Ki-67 proliferation indices and clinical...

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Source

Identifiers

PMID: 27998919
DOI: 10.1530/EJE-16-0620

Genes

AIP
GNAS
IGF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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