miR ‐34a is upregulated in AIP ‐mutated somatotropinomas and promotes octreotide resistance

Abstract excerpt

Abstract Pituitary adenomas (PAs) are intracranial tumors associated with significant morbidity due to hormonal dysregulation, mass effects and have a heavy treatment burden. Growth hormone (GH)‐secreting PAs (somatotropinomas) cause acromegaly‐gigantism. Genetic forms of somatotropinomas due to germline AIP mutations (AIPmut+) have an early onset and are aggressive and resistant to treatment with somatostatin...