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The clinical, pathological, and genetic features of familial isolated pituitary adenomas

24 Sept 2007

Abstract excerpt

Pituitary adenomas occur in a familial setting in multiple endocrine neoplasia type 1 (MEN1) and Carney's complex (CNC), which occur due to mutations in the genes MEN1 and PRKAR1A respectively. Isolated familial somatotropinoma (IFS) is also a well-described clinical syndrome related only to patients with acrogigantism. Pituitary adenomas of all types--not limited to IFS--can occur in a familial setting in the...

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PMID: 17893250
DOI: 10.1530/eje-07-0348

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