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Article

The glucose transporter GLUT1 is required for ErbB2-induced mammary tumorigenesis

1 Dec 2016

Abstract excerpt

Altered tumor cell metabolism is an emerging hallmark of cancer; however, the precise role for glucose in tumor initiation is not known. GLUT1 (SLC2A1) is expressed in breast cancer cells and is likely responsible for avid glucose uptake observed in established tumors. We have shown that GLUT1 was necessary for xenograft tumor formation from primary mammary cells transformed with the polyomavirus middle-T antigen...

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PMID: 27998284
DOI: 10.1186/s13058-016-0795-0

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