Article
Idh1 mutations contribute to the development of T-cell malignancies in genetically engineered mice.
Proceedings of the National Academy of Sciences of the United States of America - 2 Feb 2016
Hao Zhenyue, Cairns Rob A, Inoue Satoshi, Li Wanda Y, Sheng Yi, Lemonnier François, Wakeham Andrew, Snow Bryan E, Dominguez-Brauer Carmen, Ye Jing, Larsen Dana M, Straley Kimberly S, Tobin Erica R, Narayanaswamy Rohini, Gaulard Philippe, Mak Tak W
Abstract excerpt
Gain-of-function mutations in isocitrate dehydrogenase 1 (IDH1) are key drivers of hematopoietic malignancies. Although these mutations are most commonly associated with myeloid diseases, they also occur in malignancies of the T-cell lineage. To investigate their role in these diseases and provide tractable disease models for further investigation, we analyzed the T-cell compartment in a conditional knock-in (KI)...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.