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Oncogene Pathway Activation in Mammary Tumors Dictates FDG-PET Uptake

20 Sept 2014

Abstract excerpt

Increased glucose utilization is a hallmark of human cancer that is used to image tumors clinically. In this widely used application, glucose uptake by tumors is monitored by positron emission tomography of the labeled glucose analogue 2[(18)F]fluoro-2-deoxy-D-glucose (FDG). Despite its widespread clinical use, the cellular and molecular mechanisms that determine FDG uptake--and that underlie the heterogeneity...

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PMID: 25239452
DOI: 10.1158/0008-5472.can-14-1235

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