Article
Oncogene activation induces metabolic transformation resulting in insulin-independence in human breast cancer cells.
PloS one - 17 Mar 2011
Bollig-Fischer Aliccia, Dewey T Gregory, Ethier Stephen P
Abstract excerpt
Normal breast epithelial cells require insulin and EGF for growth in serum-free media. We previously demonstrated that over expression of breast cancer oncogenes transforms MCF10A cells to an insulin-independent phenotype. Additionally, most breast cancer cell lines are insulin-independent for growth. In this study, we investigated the mechanism by which oncogene over expression transforms MCF10A cells to an...
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