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Article

ppargc1a controls nephron segmentation during zebrafish embryonic kidney ontogeny.

eLife - 26 Nov 2018

Chambers Joseph M, Poureetezadi Shahram Jevin, Addiego Amanda, Lahne Manuela, Wingert Rebecca A

Abstract excerpt

Nephron segmentation involves a concert of genetic and molecular signals that are not fully understood. Through a chemical screen, we discovered that alteration of peroxisome proliferator-activated receptor (PPAR) signaling disrupts nephron segmentation in the zebrafish embryonic kidney (Poureetezadi et al., 2016). Here, we show that the PPAR co-activator ppargc1a directs renal progenitor fate. ppargc1a mutants...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30475208
DOI: 10.7554/eLife.40266
PMCID: PMC6279350

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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