Article
The protein interacting with carboxyl terminus-1 codon 389 polymorphism impairs protein interacting with carboxyl terminus-1 function and is a risk factor for uterine cervical cancer.
Molecular carcinogenesis - 1 May 2017
Yoshimoto Masafumi, Tokuda Aoi, Nishiwaki Kunihiko, Sengoku Kazuo, Yaginuma Yuji
Abstract excerpt
PICT-1 is a nucleolar protein with various tumor suppressor functions. Recently, PICT-1 expression was reported to be dramatically reduced in several cancers. To investigate the role of PICT-1 in uterine cervical carcinogenesis, we examined its gene mutations, protein expression, cellular localization, and effect on p53 stabilization. PCR-SSCP analysis of the entire coding region of PICT-1 showed that a...
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