Article
A novel functional variant (-842G>C) in the PIN1 promoter contributes to decreased risk of squamous cell carcinoma of the head and neck by diminishing the promoter activity.
Carcinogenesis - 1 Oct 2009
Lu Jiachun, Hu Zhibin, Wei Sheng, Wang Li-E, Liu Zhensheng, El-Naggar Adel K, Sturgis Erich M, Wei Qingyi
Abstract excerpt
PIN1, a new peptidyl-prolyl cis/trans isomerase, regulates the conformation of Pro-directed phosphorylation sites, revealing a new postphosphorylation regulatory mechanism. PIN1-induced conformational changes potentiate multiple oncogenic signaling pathways, and PIN1 overexpression is reported as a prevalent and specific event in human cancers. In this study, we tested the hypothesis that common polymorphisms in...
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