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Article

Structural basis of instability of the nucleosome containing a testis-specific histone variant, human H3T.

Proceedings of the National Academy of Sciences of the United States of America - 8 Jun 2010

Tachiwana Hiroaki, Kagawa Wataru, Osakabe Akihisa, Kawaguchi Koichiro, Shiga Tatsuya, Hayashi-Takanaka Yoko, Kimura Hiroshi, Kurumizaka Hitoshi

Abstract excerpt

A histone H3 variant, H3T, is highly expressed in the testis, suggesting that it may play an important role in the chromatin reorganization required for meiosis and/or spermatogenesis. In the present study, we found that the nucleosome containing human H3T is significantly unstable both in vitro and in vivo, as compared to the conventional nucleosome containing H3.1. The crystal structure of the H3T nucleosome...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20498094
DOI: 10.1073/pnas.1003064107
PMCID: PMC2890842

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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