Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human testis/sperm-specific histone H2B (hTSH2B). Molecular cloning and characterization.

The Journal of biological chemistry - 8 Nov 2002

Zalensky Andrei O, Siino Joseph S, Gineitis Arunas A, Zalenskaya Irina A, Tomilin Nikolai V, Yau Peter, Bradbury E Morton

Abstract excerpt

Human sperm, unlike the sperm of other mammals, contain replacement histones with unknown biological functions. Here, we report the identification of the novel human gene coding for a testis/sperm-specific histone H2B (hTSH2B). This variant histone is 85% homologous to somatic H2B and has over 93% homology with the testis H2B of rodents. Using genomic PCR, two genetic alleles of hTSH2B were found in the human...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Nucleus
Share to Histones

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Organ Specificity

Share to Recombinant Proteins

Share to Sequence Alignment

Share to Sequence Homology, Amino Acid

Share to Spermatozoa

Share to Testis

Source

Identifiers

PMID: 12213818
DOI: 10.1074/jbc.M206065200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human testis/sperm-specific histone H2B (hTSH2B). Molecular cloning and characterization.PMID 12213818Read ↗

Characterization of nucleosomes consisting of the human testis/sperm-specific histone H2B variant (hTSH2B).Semantic proximity Read ↗

Novel classes and evolutionary turnover of histone H2B variants in the mammalian germlineSemantic proximity Read ↗

H2A.Bbd: an X-chromosome-encoded histone involved in mammalian spermiogenesisSemantic proximity Read ↗

Histones: genetic diversity and tissue-specific gene expression.Semantic proximity Read ↗

Evolutionary origins and diversification of testis-specific short histone H2A variants in mammals.Semantic proximity Read ↗

Structural analyses of the nucleosome complexes with human testis-specific histone variants, hTh2a and hTh2b.Semantic proximity Read ↗

Evolutionary origins and diversification of testis-specific short histone H2A variants in mammalsSemantic proximity Read ↗

Human sperm telomere-binding complex involves histone H2B and secures telomere membrane attachment.Semantic proximity Read ↗

Short Histone H2A Variants: Small in Stature but not in Function.Semantic proximity Read ↗

Presence of a bi-directional S phase-specific transcription regulatory element in the promoter shared by testis-specific TH2A and TH2B histone genes.Semantic proximity Read ↗

Polar nuclear localization of H1T2, a histone H1 variant, required for spermatid elongation and DNA condensation during spermiogenesisSemantic proximity Read ↗

Histone variants and transcription regulation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.